What is the most Blister-causing game you\'ve ever played?

Mike Tyson\'s Punch Out!  Ha Ha!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Against sandman.  Give it up for old school!(NES) for the young people in the forum.

Fianl Fantasy VII because I would play it for 5-6 hours and my fingers would cramp, now I will have arthritis, but I don\'t mind.  
Better to be gaming than have a life.

The Wheel of Time books!

Yes, Jerginsoft, I\'ve read them so much, and at so many different angles, that my wrists used to cramp up!

[Bobs_Hardware]

Masturbation 2:  Back for More

had me up all night, and had blisters the whole next morning

but in actual fact, Street Fighter 2...because i played it the wrong way where i slid the end of my thumb on the pad to do a fireball, rather than twist the ball of your thumb...and it hurt  

mine would have to be mario party the first one, and that damn game where you had to rotate the control stick around that made my palm hurt for days