Buffalo= teh easy... one expressway that encircles the city, one offshoot that runs right through the middle. The only place that was easier was Sacramento. theomen will probably correct me, but I think all east-west streets are A-Z, and north-south are numbered.
The irish & polish built Buffalo, so there are a lot of roundabouts and diagonal parkways, but essentially you will end up on one of three main thoroughfares.